overview: A new PET imaging probe shows real-time brain activity occurring during the progression of autism and Alzheimer’s disease.
sauce: Emory University
Emory researchers seek to see in real time how brain diseases such as Alzheimer’s and autism spectrum disorders affect brain function in patients. That window into the brain, in turn, will allow us to develop more effective drugs to treat the more than 10 million people in the United States who live with these still puzzling conditions.
Two grants from the National Institute on Aging and the National Institute of Mental Health funded the development of novel positron emission tomography (PET) imaging probes for Alzheimer’s disease and autism spectrum disorders, and for disease progression. designed to show real-time brain activity occurring in
The award provides a total of $9.6 million over five years to support interdisciplinary teams working together through the new Positron Emission Tomography Imaging Center and Radiopharmaceutical Discovery Program in the Department of Radiology and Imaging Sciences at Emory University School of Medicine. . Collaborating departments include Pharmacology and Chemical Biology, Neurology and Psychiatry.
“We are truly honored to receive this federal support to advance our understanding of Alzheimer’s disease and autism spectrum disorders using next-level PET imaging technology.
“By collaborating with Emory’s highly qualified faculty in translational brain research, we are advancing clinical research and drug discovery to help millions of people living with Alzheimer’s disease and other forms of dementia. We can move forward effectively and quickly.”
An imaging probe project aimed at extracting target-specific information in living subjects that reveals disease stage and progression was co-investigated by co-investigators Stephen F. Traynelis, Ph.D., Professor, and Hongjie Yuan, M.D., Ph.D., Associate Professor. This is an interdisciplinary joint research with Both from Alan Levy, M.D., Ph.D., Department of Pharmacology and Chemical Biology, Emory School of Medicine, Robert W. Woodruff Professor of Neurology, Goizueta Foundation Endowed Chair for Alzheimer’s Disease Research, and Director of the Goizueta Center for Alzheimer’s Disease Research.
Intercenter and interdepartmental collaborations as part of the Autism-Related Project include Dr. Larry Young, Professor of Psychiatry and Behavioral Sciences and Director of the Center for Translational Social Neuroscience at the Emory National Primate Research Center It is included.
From Promise to Deep Impact
“This study has the potential to change the game,” said Dr. Elizabeth Krupinski, professor and vice chair of research in the Department of Radiology and Imaging Sciences.
“Dr. Liang’s projects include drug discovery, radiochemistry and translational PET imaging studies in multiple species, from rodents to non-human primates to humans. Our Team Science We are very much looking forward to supporting this fruitful collaboration that is the result of our approach, fostering cross-departmental exchanges to translate basic science discoveries into humans.”
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Vikas Sukhatme, MD, ScD, Dean of the Emory School of Medicine, agrees: This work will take place in the new Health Sciences Research Building (HSRB)-II, supported by our Center of Systems Imaging Core, a world-class research facility dedicated to improving our understanding and treatment of complex conditions. prove that you can ”
Emory: A National Leader in Advanced Imaging Innovation
Emory is a natural home for this research, said Amit Saindane, MD, MBA, professor and chair of the Department of Radiology and Imaging Sciences. “Emory Radiology has a strong track record in developing advanced imaging technologies, radiopharmaceutical discovery and translational research.”
Its record includes pioneering prostate cancer imaging, discovery of imaging agents to detect recurrent prostate cancer, and a major clinical trial of a radiotracer to guide clinical decision-making in patients with recurrent prostate cancer. included.
Saindane sees this next wave of discoveries as promising as well. “The new PET imaging tools developed by Dr. Liang and his research team show great potential to advance our understanding of these devastating neurodegenerative and neurodevelopmental diseases. We want to make it available for research to test new neurotherapeutic agents for treatment.”
About this Neuroimaging Research News
author: Brian Katsowitz
sauce: Emory University
contact: Brian Katsowitz – Emory University
image: image is public domain
