Brain Wealthy
    What's Hot

    Little Celebrities on Campus Who Will Change College Life | By Reid Zura | Starship Technologies | June 2023

    June 5, 2023

    Inclusiveness in Practice: Starship Technologies Proudly Deployed in LA | By Reid Zura | Starship Technologies | June 2023

    June 1, 2023

    Global Accessibility Awareness Day: Building Accessibility into Technology | By Ed Lovelock | Starship Technologies | May 2023

    May 18, 2023
    Facebook Twitter Instagram
    Facebook Twitter Instagram
    Brain Wealthy
    • Home
    • Anxiety

      FSU psychologist receives $3.7 million grant to combat anxiety in seniors with Alzheimer’s and cognitive impairment

      February 2, 2023

      How anxiety came to dominate the big business of medical marijuana cards in Pa.

      February 2, 2023

      How to Reduce Anxiety in Stressful Situations

      February 2, 2023

      The cat in boots The last wish taught me about anxiety

      February 2, 2023

      Inseparable cat trio with ‘separation anxiety brothers’ find new home

      February 2, 2023
    • Emotion

      Leigh-Anne Pinnock shares emotional post about embarking on her solo career

      February 2, 2023

      Ontario paramedic emotional during last radio call

      February 2, 2023

      A Pianist Faces Death and Recorded Music of Unspeakable Emotions

      February 2, 2023

      Return of home post linking Gichaara to ancestors is emotional for north coast nation

      February 2, 2023

      Mother of two sues New York school district for ‘mental distress’ caused by mask enforcement

      February 2, 2023
    • Neurology

      Gardasil Injection Lawsuit Claims HPV Vaccine Caused Neurological and Autonomic Dysfunction

      February 2, 2023

      REGENXBIO’s Duchenne Therapy RGX-202 Clinical Trial Begins Patient Recruitment

      February 2, 2023

      Aducanumab for the treatment of Alzheimer’s disease

      February 2, 2023

      Potential for Effective Comparative Studies and Treatment Approval in Epilepsy Care: Anup Patel, MD

      February 2, 2023

      Head injury does not predict memory impairment in NFL retirees, UT Southwestern study shows: Newsroom

      February 2, 2023
    • Sleep

      Review: Never Sleep Again: The Elm Street Legacy – Blu-ray

      February 2, 2023

      Get a better night’s sleep with better pillows from The Pillow Bar in Dallas

      February 2, 2023

      Is it okay to sleep with a necklace on?

      February 2, 2023

      Does tart cherry juice improve sleep?

      February 2, 2023

      Social Jet Lag, Sleep Chronotypes, and Why We Gotta Close Our Eyes and Embrace It

      February 2, 2023
    • Brain Research

      spark!Talk – video available online

      February 2, 2023

      Studies have found that obesity-related neurodegeneration mimics Alzheimer’s disease.newsroom

      February 2, 2023

      The Brain Observatory: New Museum to Participate in Museum Month

      February 1, 2023

      who wants to live forever

      February 1, 2023

      UK company makes surprise forays

      February 1, 2023
    • Brain Wealth
      1. Mental Health
      2. View All

      Research project applies a global lens to student mental health

      February 2, 2023

      DC Metro shooting suspect undergoes mental health evaluation after rampage

      February 2, 2023

      Gov. Ho-Chol unveils details of $1 billion plan to overhaul New York State’s mental health care continuum

      February 2, 2023

      Boston, we have a problem: data on mental health and practice come in

      February 2, 2023

      Research project applies a global lens to student mental health

      February 2, 2023

      DC Metro shooting suspect undergoes mental health evaluation after rampage

      February 2, 2023

      Gov. Ho-Chol unveils details of $1 billion plan to overhaul New York State’s mental health care continuum

      February 2, 2023

      Boston, we have a problem: data on mental health and practice come in

      February 2, 2023
    Brain Wealthy
    Home»Neurology»Treatment with nusinersen improved motor function in infantile-onset SMA for up to 5 years
    Neurology

    Treatment with nusinersen improved motor function in infantile-onset SMA for up to 5 years

    brainwealthy_vws1exBy brainwealthy_vws1exJanuary 10, 2023No Comments2 Mins Read
    Facebook Twitter LinkedIn Telegram Pinterest Tumblr Reddit WhatsApp Email
    Share
    Facebook Twitter LinkedIn Pinterest Email


    January 10, 2023

    Read in 2 minutes

    Source/Disclosure

    sauce:

    Castro D, et al.Long-Term Safety and Efficacy of Nusinersen in Infantile-Onset Spinal Muscular Atrophy: 5 Years
    Costume from SHINE. Presentation: International Scientific Conference on Spinal Muscular Atrophy. October 21-23, 2022. Barcelona, ​​Spain.

    Disclosure:
    Castro does not report related financial disclosures.


    Add topic to email alert

    Get an email when new articles are posted

    Enter your email address to receive an email when new articles are posted .

    Your request could not be processed. Please try again later. If this issue persists, please contact us at customerservice@slackinc.com.

    According to a poster presented at the International Scientific Conference on Spinal Muscular Atrophy, treatment with nusinersen led to sustained and improved motor function up to five years after the first dose in infants with spinal muscular atrophy.

    “Long-term follow-up in the SHINE study will allow us to better understand emerging phenotypes in SMA.” Diana Castro, M.D. “In the absence of well-designed and controlled studies, physicians cannot advise new patients and their families on what to expect and what is realistic as they navigate life with SMA. You can not.”

    Baby playing with blocks.

    Interim results from the SHINE study in infantile-onset spinal muscular atrophy type 1 patients showed that treatment with nusinersen led to improved motor function. Source: Adobe Stock.

    Castro et al. sought to investigate the safety and efficacy of the antisense oligonucleotide nusinersen in adults and children with infantile-onset spinal muscular atrophy that transitioned from the ENDEAR trial to the SHINE trial. ENDEAR is a sham-controlled Phase 3 trial of nusinersen for up to 394 days in symptomatic infantile-onset patients with probable SMA Type 1 and SHINE is an ongoing, open-label extension study .

    A total of 105 participants (80 started on ENDEAR and 25 on SHINE) received nusinersen in the SHINE trial, with a median duration of 5.3 years. Participants were analyzed in three groups according to age at first study dose and timing of first dose. Age 6 months to less than 10 months with previous nusinersen or sham surgery at ENDEAR (n = 29). From 10 months of age he was less than 23 months old and started nusinersen on SHINE after receiving her sham on ENDEAR (n = 25).

    According to the results, the Philadelphia Children’s Hospital mean neuromuscular infant test scores from baseline to day 1,538 for all age groups (<6 months, 27 to 48.3; 6 months to <10 months, 25.9); from 43.8, from 10 months to less than 10 months). At 23 months (17.4 to 25.2), modified upper extremity module and Hammersmith Functional Motor Scale Expanded scores also continued to improve within the two youngest groups from baseline to 1,080 days.

    Additionally, no serious adverse events were considered treatment-related as of the data cutoff date. The most common adverse events were fever, pneumonia, and upper respiratory tract infection, and the most common serious adverse events included pneumonia, dyspnea, and respiratory failure.

    “The results from the SHINE trial show that patients continue to gain motor function, reach milestones after an average of five years of treatment, and have no significant side effects at up to seven years of follow-up,” said Castro. “With any therapy, it’s important to be able to continue to look forward to new motor milestones, even if they’re delayed.”


    Add topic to email alert

    Get an email when new articles are posted

    Enter your email address to receive an email when new articles are posted .

    Your request could not be processed. Please try again later. If this issue persists, please contact us at customerservice@slackinc.com.



    Source link

    Share. Facebook Twitter Pinterest LinkedIn Tumblr Telegram Email
    Previous ArticleGoogle Assistant sleep timer for pausing music doesn’t work on some Nest devices
    Next Article Daniel Howell talks mental health
    brainwealthy_vws1ex
    • Website

    Related Posts

    Gardasil Injection Lawsuit Claims HPV Vaccine Caused Neurological and Autonomic Dysfunction

    February 2, 2023

    REGENXBIO’s Duchenne Therapy RGX-202 Clinical Trial Begins Patient Recruitment

    February 2, 2023

    Aducanumab for the treatment of Alzheimer’s disease

    February 2, 2023
    Add A Comment

    Leave A Reply Cancel Reply

    Top Posts

    Subscribe to Updates

    Get the latest sports news from SportsSite about soccer, football and tennis.

    This website provides information about Brain and other things. Keep Supporting Us With the Latest News and we Will Provide the Best Of Our To Makes You Updated All Around The World News. Keep Sporting US.

    Facebook Twitter Instagram Pinterest YouTube
    Top Insights

    Top UK Stocks to Watch: Capita Shares Rise as it Unveils

    January 15, 2021
    8.5

    Digital Euro Might Suck Away 8% of Banks’ Deposits

    January 12, 2021

    Oil Gains on OPEC Outlook That U.S. Growth Will Slow

    January 11, 2021
    Get Informed

    Subscribe to Updates

    Get the latest creative news from FooBar about art, design and business.

    © 2023 brainwealthy. Designed by brainwealthy.
    • Home
    • Contact us
    • DMCA
    • Privacy Policy

    Type above and press Enter to search. Press Esc to cancel.