January 31, 2023
Read in 2 minutes
Smoking cessation is associated with a lower risk of dementia, such as Alzheimer’s disease and vascular dementia, compared with maintaining or reducing smoking intensity. JAMA network open.
“Approximately 152 million people are expected to be affected by dementia by 2050.” Su-Min Jeong, MD, Written by the School of Medicine and colleagues at the Seoul National University School of Medicine, South Korea. “Smoking is a well-known risk factor for dementia, and he has the third highest rate of dementia attributable to the population.”
Jeong et al. conducted a cohort study using data from the Korean National Health Insurance Service database to determine whether smoking cessation or smoking cessation was associated with dementia risk. 2009 and he was a participant aged 40 or older who underwent a physical examination in 2011 and smoked at the time of initial examination.
Researchers surveyed participants according to duration of smoking and average number of cigarettes smoked per day, quitting (quit smoking), reducer I (at least 50% reduction in cigarettes smoked per day), reducer II (cigarettes smoked per day) reduction in the number of cigarettes smoked). 20% to 50% more cigarettes per day), Maintainer (maintain less than 20% cigarettes per day), or Increaser (increase the number of cigarettes per day by at least 20% gain).
Primary outcomes of interest were newly diagnosed dementia identified by prescribed nootropics and diagnostic code.
Results showed that 789,532 participants (mean age 52.2 years, 95.8% male) were included in the cohort. At baseline testing, more than half of the participants were heavy smokers (53.8%), 37.5% were moderate smokers, and 8.8% were light smokers. At follow-up visits, 14.6% of participants quit smoking and 21.9% reduced smoking. More than 15% of participants said he increased smoking from 2009 to 2011.
During a median follow-up of 6.3 years, researchers reported 11,912 dementia events, including 8,800 Alzheimer’s disease and 1,889 vascular dementia events. Participants who quit smoking had a significantly lower risk of all dementias compared with those who maintained their smoking habit (adjusted HR = 0.92; 95% CI, 0.87-0.97).
Conversely, participants who reduced the number of cigarettes smoked by 50% or more had a significantly higher risk of all dementia (aHR = 1.25; 95% CI, 1.18-1.33), compared to those who smoked 50% more cigarettes. participants who were more likely (aHR = 1.12; 95% CI, 1.06-1.18), compared with the Advocate group.
“This cohort study showed that smoking cessation is associated with a reduced risk of all dementias, including Alzheimer’s disease. [vascular dementia], compared to sustained smoking intensity,” wrote Jeong and colleagues. “However, a reduction in smoking was associated with an increased risk of dementia. Therefore, smoking cessation, rather than smoking cessation, should be emphasized to reduce the disease burden of dementia.”