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On January 30, 2023, we will: European Journal of Preventive Cardiology We assessed the existence and directionality of a causal relationship between sleep apnea (SA) or snoring and cardiovascular disease (CVD).
Researchers conducted a two-way, two-sample Mendelian randomized study involving 523,366 participants. Of these, 25,008 had a single nucleotide polymorphism associated with SA and 172,050 had a single nucleotide polymorphism associated with snoring. Multivariate Mendelian randomization was used to assess the direct effect of SA on CVD after adjusting for body mass index (BMI).
After the research team modified multiple tests, the inverse variance-weighted mean showed that SA and snoring increased the risk of hypertension (HTN) (odds ratio) [OR] 1.03, 95% CI 1.02-1.05; OR 1.05, 95% CI 1.03-1.07) and CAD (OR 1.41, 95% CI 1.19-1.67; OR 1.61, 95% CI 1.26-2.07), false discovery rate (FDR) <.05。 いびきと SA は、心房細動、心不全、または脳卒中と関連していませんでした。 HTN は SA のリスク増加と関連していたが (OR 1.53、95% CI 1.04-2.25)、この関連性は多重比較に合格しなかった (FDR >.05).
Note from author
“Our results suggest that SA and snoring increase the risk of hypertension and CAD, and these associations may be partially driven by BMI. We found no evidence of CVD causally related to snoring.”