Adolescents and adults with drug-resistant epilepsy (DRE) have fewer seizures after adhering to the Modified Atkins Diet (MAD) and receiving standard medications, according to a study published online Jan. 4. and improved behavioral problems. neurology.
“MAD therapy was effective, feasible, well tolerated, and improved compliance with seizure reductions in adolescents and adults with DRE,” said the Department of Neurology, All India Institute of Medical Sciences, New Delhi. Lead author Mala Manral, Ph.D. writes: , and colleagues. “Reduced seizure frequency reflected in improved quality of life for all patients in the intervention group compared with the control group.”
Researchers noted that one third of the 70 million people with epilepsy worldwide are resistant to antiepileptic drugs. Since most research on the use of diet as an adjunctive treatment for intractable epilepsy has focused on children, combining diet with standard pharmacotherapy has been shown to reduce seizure frequency and improve patient outcomes. are focused on adolescents and adults to determine whether it is more effective than medication in ‘ Psychological results after 6 months.
The team conducted a randomized controlled trial from August 2015 to April 2019 among people enrolled in outpatient clinics of tertiary care referral centers in India. The researchers randomly assigned 160 patients (80 adults aged 18 to 55 years and her 80 adolescents aged 10 to 17 years) to an intervention or control group. 52 patients later discontinued the study. At baseline, the participant had no more than two seizures in a month, even though he was on at least the maximum dose of three antiepileptic drugs and had not used a diet in the past year. was causing
“Many patients who are not good candidates for surgery or who decline surgery benefit from dietary interventions,” the researchers said.[MAD] It contains about 65% fat, 25% protein and 10% carbs, so we aim for a 1:1 ratio of fat to carbs and protein to improve palatability and flexibility. Therefore, the MAD and low glycemic index diets are less restrictive alternatives to the ketogenic diet because they are not restricted in protein and calories. ”
Study participants limited their carbohydrate intake to 20 gm per day, and researchers encouraged them to consume high-fat, low-carbohydrate foods. Participants were allowed to eat as much protein as they wanted. They also supplemented their diet with multivitamins and minerals.
Parents and caregivers of the participants kept daily records tracking seizures, meals eaten, and food intolerances. They also used keto dipsticks to measure ketones in their urine three times a day.
Researchers assessed participants at baseline, 3 months, and 6 months. After 6 months, a seizure reduction of 50% or more was observed in 26.2% of the intervention group compared to 2.5% of the control group. They also observed an improvement in quality of life in approximately 52.1% of the intervention group and approximately 42.5% of the control group.
“But the behavior [sic] The score could be performed in 49 patients and showed improvement in the intervention and control groups (65.6±7.9 vs 71.4±8.1, p = 0.015) at the end of the study,” the researchers said.
Although MAD was effective in suppressing seizures, the team concluded that “further studies are needed to assess its efficacy.”
“Future studies will be needed to identify neurophysiological and genetic biomarkers associated with MAD response,” they added. We can offer alternative treatments to standard treatments. ”
Dr. Manlal had no disclosures.