WEDNESDAY, Jan. 4, 2023 (HealthDay News) — Exposure to diabetes in utero increases the risk of neurodevelopmental disorders (NDD) in offspring, according to a study published online Dec. 21. Developmental Medicine and Pediatric Neurology.
Dr. Kuan-Ru Chen, National Cheng Kung University Hospital, Tainan, Taiwan, and colleagues conducted a retrospective cohort study of 877,233 singletons born between 2004 and 2008 in Taiwan. Using health insurance claims data, to 2015, including autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), developmental delay, intellectual disability, cerebral palsy, and epilepsy/infantile seizures We followed the child for his diagnosis of NDD. The relative risk of NDD associated with maternal diabetes was estimated.
Overall, 0.04, 1.00, and 10.28% of children were exposed in utero to type 1 diabetes (T1DM), type 2 diabetes (T2DM), and gestational diabetes (GDM), respectively. The researchers found that the greatest impact on NDD was seen in her T1DM, followed by T2DM and GDM. Developmental delay, intellectual disability, and an increased risk of epilepsy/intellectual convulsions were seen in offspring associated with T1DM. There was an increased risk of ASD, ADHD, developmental delay, intellectual disability, cerebral palsy, and epilepsy/intellectual seizures associated with type 2 diabetes. An increased risk of delay was seen.
“Mechanistic studies are needed to investigate how maternal conditions such as diabetes shape brain development in utero,” the co-authors said in a statement.
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