Brain Wealthy
    What's Hot

    DC Metro shooting suspect undergoes mental health evaluation after rampage

    February 2, 2023

    Is it okay to sleep with a necklace on?

    February 2, 2023

    A Pianist Faces Death and Recorded Music of Unspeakable Emotions

    February 2, 2023
    Facebook Twitter Instagram
    Facebook Twitter Instagram
    Brain Wealthy
    • Home
    • Anxiety

      How to Reduce Anxiety in Stressful Situations

      February 2, 2023

      The cat in boots The last wish taught me about anxiety

      February 2, 2023

      Inseparable cat trio with ‘separation anxiety brothers’ find new home

      February 2, 2023

      Declining sales of COVID-19 drugs. Pharmacies were warned against mailing abortion pills.Depression, pollution leading to anxiety

      February 2, 2023

      Finding Freedom – Marisa Peer and Arcretic Partners to Help Millions Overcome Anxiety with Self-Hypnosis

      February 2, 2023
    • Emotion

      A Pianist Faces Death and Recorded Music of Unspeakable Emotions

      February 2, 2023

      Return of home post linking Gichaara to ancestors is emotional for north coast nation

      February 2, 2023

      Mother of two sues New York school district for ‘mental distress’ caused by mask enforcement

      February 2, 2023

      Emotional (mis)perceptions: Is the EU missing the mark?

      February 2, 2023

      Cody Rhodes’ emotional message ahead of WrestleMania 39’s main event

      February 2, 2023
    • Neurology

      Aducanumab for the treatment of Alzheimer’s disease

      February 2, 2023

      Potential for Effective Comparative Studies and Treatment Approval in Epilepsy Care: Anup Patel, MD

      February 2, 2023

      Head injury does not predict memory impairment in NFL retirees, UT Southwestern study shows: Newsroom

      February 2, 2023

      Severity of restless leg syndrome in MS was reduced by exercise games

      February 2, 2023

      Educating and palliating interdisciplinary care teams to treat Parkinson’s disease: Eli Pollard

      February 2, 2023
    • Sleep

      Is it okay to sleep with a necklace on?

      February 2, 2023

      Does tart cherry juice improve sleep?

      February 2, 2023

      Social Jet Lag, Sleep Chronotypes, and Why We Gotta Close Our Eyes and Embrace It

      February 2, 2023

      Too much sex and too little sleep can kill these endangered marsupials.smart news

      February 2, 2023

      Best Sleep Techniques To Help You Catch More ZZZs

      February 2, 2023
    • Brain Research

      spark!Talk – video available online

      February 2, 2023

      Studies have found that obesity-related neurodegeneration mimics Alzheimer’s disease.newsroom

      February 2, 2023

      The Brain Observatory: New Museum to Participate in Museum Month

      February 1, 2023

      who wants to live forever

      February 1, 2023

      UK company makes surprise forays

      February 1, 2023
    • Brain Wealth
      1. Mental Health
      2. View All

      DC Metro shooting suspect undergoes mental health evaluation after rampage

      February 2, 2023

      Gov. Ho-Chol unveils details of $1 billion plan to overhaul New York State’s mental health care continuum

      February 2, 2023

      Boston, we have a problem: data on mental health and practice come in

      February 2, 2023

      Big Brother Meets Bedlam: Resisting Mental Health Surveillance Tech

      February 2, 2023

      DC Metro shooting suspect undergoes mental health evaluation after rampage

      February 2, 2023

      Gov. Ho-Chol unveils details of $1 billion plan to overhaul New York State’s mental health care continuum

      February 2, 2023

      Boston, we have a problem: data on mental health and practice come in

      February 2, 2023

      Big Brother Meets Bedlam: Resisting Mental Health Surveillance Tech

      February 2, 2023
    Brain Wealthy
    Home»Neurology»Gut bacteria influence brain health, study in mice
    Neurology

    Gut bacteria influence brain health, study in mice

    brainwealthy_vws1exBy brainwealthy_vws1exJanuary 13, 2023No Comments6 Mins Read
    Facebook Twitter LinkedIn Telegram Pinterest Tumblr Reddit WhatsApp Email
    Share
    Facebook Twitter LinkedIn Pinterest Email


    A growing body of evidence indicates that the tens of trillions of microbes that normally inhabit our gut, the so-called gut microbiome, have far-reaching effects on how our bodies function. Members of the microbial community produce vitamins, help digest food, prevent the overgrowth of harmful bacteria, regulate the immune system, and more. A new study suggests that the gut microbiome also plays an important role in brain health.

    This study in mice found that gut bacteria influence the behavior of immune cells throughout the body by producing compounds such as short-chain fatty acids. This includes things in the brain that can damage brain tissue and exacerbate neurodegeneration in conditions such as Alzheimer’s disease. disease. Findings published in the journal on January 13 chemistryopens up the possibility of reshaping the gut microbiota as a way to prevent or treat neurodegeneration.

    “After as little as one week of antibiotics in young mice, we saw permanent changes in the gut microbiome, immune response, and the degree of neurodegeneration associated with a protein called tau experienced with age,” he said. Author David M. Holtzman says: MD, Barbara Burton and Reuben M. Morris III Distinguished Professor of Neurology. “What’s interesting is that by manipulating the gut microbiome, you can affect the brain without putting anything directly into it.”

    Evidence is accumulating that the gut microbiota of patients with Alzheimer’s disease may differ from those of healthy individuals. It is not clear how changes in

    To determine whether the gut microbiome may have a causative role, researchers altered the gut microbiota in mice prone to develop Alzheimer’s-like brain damage and cognitive deficits. Did. Mice have been genetically engineered to express a mutant form of the human brain protein tau, which accumulates and damages neurons by 9 months of age, causing brain atrophy.They also carried human variants appointment gene, the major genetic risk factor for Alzheimer’s disease.who has one copy of APOE4 Variants are three to four times more likely to develop the disease than people with more common variants. APOE3Mutant.

    Along with Holzmann, the research team includes gut microbiome experts and co-authors Jeffrey I. Gordon, MD, and Robert J. Glazer, MD, directors of the Edison Family Center for Genome Science and Systems Biology. I was. Dr. Dong-Oh Seo, First Author, Neurology Instructor. Co-author Sangram S. Sisodia, Ph.D., is professor of neurobiology at the University of Chicago.

    Such transgenic mice do not acquire a gut microbiota when housed in germ-free conditions from birth, and brain damage at 40 weeks of age is more pronounced than that of mice with normal mouse microbiota. was also shown to be much lower.

    When such mice were housed under normal non-sterile conditions, they developed a normal microbiome. However, administration of antibiotics at 2 weeks of age permanently altered the composition of bacteria within the microbiome. The amount of overt brain damage was also reduced in male mice at 40 weeks of age. The protective effect of microbiome alterations was more pronounced in virus-carrying male mice. APOE3 Variants over high-risk individuals APOE4variant, possibly due to the detrimental effects of APOE4Some of the protections have been revoked, researchers say. Antibiotic treatment had no significant effect on neurodegeneration in female mice.

    “We already know from studies of brain tumors, normal brain development, and related topics that immune cells in male and female brains respond very differently to stimulation,” Holtzman said. “Thus, it’s hard to say exactly what this means for men and women living with Alzheimer’s disease and related disorders, but it’s so surprising that we saw gender differences in responses when we manipulated the microbiome. It’s not that.”

    Further experiments linked three specific short-chain fatty acids, compounds produced as metabolites by certain types of gut bacteria, to neurodegeneration. All three of these fatty acids were deficient in mice with altered gut microbiota by antibiotic treatment and were undetectable in mice without gut microbiota.

    These short-chain fatty acids caused neurodegeneration by activating immune cells in the bloodstream, which somehow appeared to activate immune cells in the brain to damage brain tissue. When middle-aged mice with no microbiome were given three short-chain fatty acids, immune cells in the brain became more responsive and the brain showed more signs of tau-related damage.

    “This study may provide important insights into how the microbiome influences tau-mediated neurodegeneration, suggesting that therapeutics that alter the gut microbiome may contribute to the development or progression of neurodegenerative diseases.” It suggests that it may have an impact.” Stroke (NINDS) provided some of the research funding.

    This finding suggests new approaches to prevent and treat neurodegenerative diseases by altering the gut microbiota with antibiotics, probiotics, specialized diets, or other means.

    “What I would like to know is that if we take a mouse that is genetically destined to develop a neurodegenerative disease and manipulate the microbiome just before the animal begins to show signs of damage, we can slow or prevent neurodegeneration. Or is it?” asked Holzmann. “It’s the same as starting treatment in late middle-aged people who are still cognitively normal but are on the verge of developing the disorder. These types of neurodegeneration can be treated before neurodegeneration is first apparent.” If we can start a treatment in a genetically sensitized adult animal model and show it works, it could be something that can be tested in humans.



    Survey method

    experimental research

    Research theme

    animal

    article title

    ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy.

    Article publication date

    January 13, 2023

    COI statement

    DMH is a co-founder of C2N Diagnostics, LLC and participates on the scientific advisory boards and/or consulting of Genentech, Denali, C2N Diagnostics, Cajal Neurosciences, and Alector. DMH is the inventor of a patent licensed by the University of Washington to his C2N Diagnostics for the therapeutic use of anti-tau antibodies and a patent licensed by the University of Washington to Eli Lilly for humanized anti-Ab antibodies. The Holzmann Institute has received research grants from the National Institutes of Health, CURE Alzheimer’s Foundation, Rainwater Foundation, JPB Foundation, Good Ventures, Novartis, Eli Lilly, and NextCure. The authors declare no other competing interests.

    Disclaimer: AAAS and EurekAlert! EurekAlert! is not responsible for the accuracy of news releases posted. Use of information by contributors or via the EurekAlert system.



    Source link

    Share. Facebook Twitter Pinterest LinkedIn Tumblr Telegram Email
    Previous Articlefind the right words for a lovely feeling
    Next Article K Sujatha Rao writes: Policy makers need to take mental health more seriously
    brainwealthy_vws1ex
    • Website

    Related Posts

    Aducanumab for the treatment of Alzheimer’s disease

    February 2, 2023

    Potential for Effective Comparative Studies and Treatment Approval in Epilepsy Care: Anup Patel, MD

    February 2, 2023

    Head injury does not predict memory impairment in NFL retirees, UT Southwestern study shows: Newsroom

    February 2, 2023
    Add A Comment

    Leave A Reply Cancel Reply

    Top Posts

    Subscribe to Updates

    Get the latest sports news from SportsSite about soccer, football and tennis.

    This website provides information about Brain and other things. Keep Supporting Us With the Latest News and we Will Provide the Best Of Our To Makes You Updated All Around The World News. Keep Sporting US.

    Facebook Twitter Instagram Pinterest YouTube
    Top Insights

    Top UK Stocks to Watch: Capita Shares Rise as it Unveils

    January 15, 2021
    8.5

    Digital Euro Might Suck Away 8% of Banks’ Deposits

    January 12, 2021

    Oil Gains on OPEC Outlook That U.S. Growth Will Slow

    January 11, 2021
    Get Informed

    Subscribe to Updates

    Get the latest creative news from FooBar about art, design and business.

    © 2023 brainwealthy. Designed by brainwealthy.
    • Home
    • Contact us
    • DMCA
    • Privacy Policy

    Type above and press Enter to search. Press Esc to cancel.