Extracorporeal CPR does not lead to more favorable neurological outcomes

For out-of-hospital cardiac arrest patients, extracorporeal cardiopulmonary resuscitation (CPR) does not improve favorable neurological outcomes compared with conventional CPR, according to a study published Jan. 26. New England Journal of Medicine.

Martje M. Suverein, MD, Maastricht University, The Netherlands, and colleagues randomized out-of-hospital cardiac arrest patients aged 18 to 70 years to receive bystander CPR, with early ventricular arrhythmias and no recurrence. was. Survival with a favorable neurological outcome at his 30-day time point on spontaneous circulation within 15 minutes after initiation of CPR to receive extracorporeal CPR or conventional her CPR was assessed as the primary outcome .

The researchers found that 20% and 16% of patients in the extracorporeal CPR and conventional CPR groups, respectively, were alive and had favorable neurological outcomes after 30 days (odds ratio 1.4; 95 % CI 0.5 to 3.5; P = 0.52). The two groups had similar numbers of serious adverse events reported per patient.

“Available data do not yet support the widespread use of extracorporeal CPR in patients with witnessed out-of-hospital cardiac arrest,” wrote the authors of an accompanying editorial. Evaluation will require much larger studies with strong statistical power to extrapolate the potential benefits of this resource-intensive strategy.”

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