January 11, 2023
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Jelic does not report related financial disclosures. See research for relevant financial disclosures of all other authors.
According to a study published in , healthy women who delayed their usual bedtime by 1.5 hours showed endothelial dysfunction that increased their risk of cardiovascular disease. Chronology of the American Thoracic Society.
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“Our findings provide the first biological evidence that delaying bedtime by just an hour or two, a common behavior in this social media age, impairs vascular health. .” Three companies JerrickMD, He is director of the Center for Sleep Medicine and professor of medicine at Columbia University Medical Center, he told Helio. “Over time, early damage from sleep deprivation can lead to cardiovascular disease.”
In a randomized crossover clinical trial, Jelic and colleagues studied 35 healthy women (mean age 36 ± 14 years, BMI 25 ± 3 kg/m2).251% Caucasians) were getting 7–9 hours of sleep each day to determine whether sleep deprivation (SD) could lead to endothelial dysfunction and increase the risk of cardiovascular disease.
The researchers conducted this study in two parts. First, actigraphy obtained 2 weeks prior to randomization, 6 weeks of adequate sleep (AS) stages based on bedtime and wakeup times obtained from her screening results, or 6 A woman was randomly assigned to her SD stage for the week. Her bedtime was delayed by 1.5 hours, but her wake-up time remained the same as at baseline. After this study period, there was a 6-week span with no intervention, followed by another 6-week period in which participants followed the opposite sleep stage from the previous sleep stage.
The researchers used a linear mixed-effects model to assess differences in brachial artery flow-mediated dilatation (FMD) between groups. This was the main result of the study. They further assessed the messenger ribonucleic acid expression of endothelial nitric oxide synthase (Enos) and endothelial cell (EC) inflammation.
Of the total cohort, 32 women had investigational data for both AS and SD. Her remaining three women completed the AS phase only.
Following comparable baseline measurements of brachial artery diameter, researchers found that SD reduced brachial artery FMD compared with AS (mean, 7.35% ± 2.15% vs. 8.65% ± 2.42%; P. = .02).
In evaluating the secondary outcomes, researchers observed that SD was associated with decreased expression of messenger ribonucleic acid Enos (0.4 ± 0.37 FC vs. 1 ± 1.76 FC).
Evaluating ECs collected for inflammation, the researchers found that SD increased endothelial nuclear factor kappa B nuclear fluorescence area by 87% (mean, 2.04 ± 2.16 m2versus 1.09 ± 0.52 m2; P. = .01).
“We were surprised to find consistent detrimental effects on vascular (vascular) function after relatively mild sleep deprivation in perfectly healthy women,” Jelic told Healio.
Jerick added that sleep should be addressed in daily practice.
“Ask about sleep habits and counsel on the importance of getting enough sleep should be a routine part of health care,” Jerick said.
“In the future, it will be important to study the molecular mechanisms that mediate these changes to develop new therapies that target vascular damage in sleep-deprived settings,” she added.
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Three companies JerrickMD, You can reach me at firstname.lastname@example.org.