Members of the Duke Neurology Department advanced the field of clinical and translational neuroscience this November, contributing 16 new peer-reviewed studies. Highlights include a historical review of the neurocritical care specialty written by Cherylee Chang, M.D., and Kristi Tempro, M.D., the 68th ALSU tangled survey of alternative therapies for amyotrophic lateral sclerosis. entries, and investigation of sex-specific differences in gene expression. Underlying the risk of depressive symptoms in late-onset Alzheimer’s disease was written by her lead author, Dr. Ornit Chiba-Falek. For summaries of these and other studies, read the paragraphs below and find links to the original articles themselves.
headache and facial pain
- Roshni Dhoot, MD, and Sweta Sengupta, MD, wrote a case report of an 18-year-old man who experienced painful ophthalmoplegic neuropathy with headache and oculomotor palsy. Read the report in the latest issue of . headache.
- Tau aggregates are present in Alzheimer’s disease (AD) and other neurodegenerative diseases known as ‘tauopathies’ and are a potential source of tauopathy biomarker discovery. John Ervin and Shih-Hsiu “Jerry” Wang, MD, MS contributed an article that found that site-specific p-tau antibodies could not only distinguish between AD and non-AD brains, but also between AD and rare tauopathies. did.read the article from ACS Chemical Neuroscience Here.
- Dr. Brenda Plassman contributed to a new study examining the association between amyloid PET scan results and the possibility of mild cognitive impairment or dementia diagnosis and advance directives.Read what her research found BMC palliative care.
Multiple sclerosis and neuroimmunology
- Hypothermia is a rare symptom of multiple sclerosis (MS) that can lead to dangerous or fatal clinical outcomes. Senior authors Suma Shah, MD and Duke M.D. student Nidhila Masha wrote a recent case report of a patient with acute hypothermia without active MS flares. This article describes this case and its implications for hypothermia in MS.read in the latest issue of Neuroimmune report.
- Neuromyelitis optica spectrum disorder (NMOSD), a rare autoimmune disease, has been thought to have a progressive disease course, but factors such as seropositivity and serum titer levels of antibodies to aquaporin 4 (AQP4) effects have not been fully investigated. Senior authors Suma Shah (MD) and Duke medical students Nidhila Masha, Dorlan Kimbrough (MD), Christopher Eckstein (MD), Nicholas Hudak (PA-C, MMS), Mark Skeen (MD), and Michael Lutz (PhD) I looked back. His 53 chart review in this state. Their analysis provides an up-to-date, updated view of the clinical course of NMOSD and a more favorable view of its disease course than previous studies.read the article at Multiple Sclerosis and Related Diseases
- Anti-NMDA receptor encephalitis (NMDARe), an autoimmune brain disease, is characterized by antibodies specific for NMDA receptors in CSF. Senior authors Christopher Eckstein, M.D., and recent graduates of Duke Medical School, James Jaraputo, M.D., Megha Gupta, M.D., and M. Elizabeth Diahake, M.D. neurology A journal article discussing recent research on using the neurofilament light chain (NfL) to differentiate between NMDARe and psychosis-induced first-episode psychosis. Read that discussion here.
- Neurocritical Care Fellows Christy Templo, M.D., and Sherry Lee Chan, M.D., wrote a review article discussing the history of neurocritical care as a subspecialty. This article reviews the interdisciplinary origins of this specialty and its critical role in providing patient care.read in the latest issue of critical care clinic.
- The ALSUntangled series reviews alternative and off-label treatments for people with amyotrophic lateral sclerosis (PALS). Richard Bedlack, M.D., Ph.D., senior author of his 68th entry in this series, examines existing evidence and potential for ozone therapy and supports studies in cell or animal models, but this condition We do not recommend ozone therapy for people living inRead their full analysis amyotrophic lateral sclerosis and frontotemporal degeneration.
Parkinson’s disease and movement disorders
Stroke and Vascular Neurology
- Low-intensity transcranial focused ultrasound (LI-tFUS) has received considerable attention as a promising noninvasive neuromodulation technique for examining the human brain. A new article explores wave propagation of her LI-tFUS in human skulls to advance our understanding of how changes in ultrasound frequency and skull morphology affect wave propagation through the skull. increase. Wuwei “Wayne” Feng, MD, MS, Pratik Chhbatbar, MD, PhD, and Taewon Kim, MD, PhD contributed to this article. medical physics. Read it here.
- A specialized form of transcranial light therapy, near-infrared laser therapy, has been tested as an acute stroke treatment in three large clinical trials. A new review article describes the putative mechanism of photostimulation in the stroke setting, highlights barriers and challenges during the translation process, evaluates photostimulation parameters, and explores future opportunities for this treatment for future stroke treatments. Wuewei “Wayne” Feng, MD, MS, Pratik Chhatbar, MD, Swaroop Pawar, MD, Cherylee Chang, MD, Shreyansh Shah, MD, Estate Sokhadze, PhD, Alexis Domeracki, and Christine Park contributed to this study. Did.load Translational Stroke Study.
translational brain science
- Lead authors Alexandra Badea, PhD, Kim Johnson, and Rich O’Brien, MD, contributed a new article revealing predictive brain networks associated with Alzheimer’s disease risk factors such as age, gender and genotype. read the article at cerebral cortex.
- Senior authors Ornit Chiba-Falek, Ph.D., Michael Lutz, Ph.D., Suraj Upadhya, and Daniel Gingerich author a new study that finds gender differences in gene expression that underlie the risk of depressive symptoms in late-onset Alzheimer’s disease .read their article in the latest issue of biomolecules.
- Microgels are the building blocks of microporous annealed particle (MAP) scaffolds and serve as platforms for both in vitro cell culture and in vivo tissue repair. Tatiana Segura, Ph.D., describes microgel fabrication, lyophilization, rehydration, and microgel annealing by bioorthogonal cross-linking for her 3D cell culture in vitro to control the particle fraction of MAP scaffolds. was the senior author of the new article to cover.Please read at Journal of Visualized Experiments.
- Repeated mild traumatic brain injuries are known to increase the risk of Parkinson’s disease, but the details of this process have not been fully elucidated. Dr. Andrew West contributed new research to shed light on this area. West and his colleagues have devised an injury device that delivers repetitive mild His TBI that does not require surgery to rats, intracranially injecting preformed fibers with recombinant His αSyn. thereby induced human-like PD pathology.read what they found Acta Neuropathologica Communications.