overview: A new test that measures dopamine levels in body fluids could help detect depression, Parkinson’s disease, and other disorders characterized by abnormal dopamine levels.
Altered levels of the neurotransmitter dopamine are evident in various conditions such as Parkinson’s disease and depression.
In a study published in Chemistry Selectresearchers describe a rapid, sensitive and simple test for determining dopamine levels in bodily fluids.
This method could help clinicians detect abnormal blood levels of dopamine in their patients, potentially enabling early detection of disease.
The method relies on what are called carbon quantum dots, a class of carbon nanomaterials with photoluminescent properties, and an ionic liquid composed of several inorganic anions and organic cations that exist in liquid form at room temperature. doing.
“The proposed electrochemical sensor is an exceptional advance in dopamine detection and may pave the way for molecular diagnostics of neurological disorders,” the authors write.
About this dopamine research news
author: Sarah Henning-Stout
contact: Sarah Henning-Stout – Wiley
image: image is public domain
Original research: open access.
“Electrochemical sensors based on carbon quantum dots and ionic liquids for selective detection of dopamine,” Zahra Nazari et al. chemical select
Electrochemical sensors based on carbon quantum dots and ionic liquids for selective detection of dopamine
Dopamine (DA) as a neurotransmitter plays a pivotal role in the central nervous system. Due to the varying levels of DAs in various neurological diseases, the development of a rapid, sensitive, and simple analytical approach for determining DAs in body fluids is highly applicable.
In this study, a novel electrochemical sensor based on carbon paste electrodes (CPE) modified with ionic liquids (ILs) and carbon quantum dots (CQDs) for measuring DA by uric acid and ascorbic acid was developed. ILs and CQDs were synthesized and characterized for specific properties such as composition, emission, size distribution and morphology.
Altered CPE and different DA concentrations were then determined by cyclic voltammetry. The modified electrode showed excellent electrocatalytic activity for DA oxidation.
Under optimal conditions, the calibration curve for DA was linear in phosphate buffer (pH = 7.4) from 0.1 to 50 µM, with a limit of detection of 0.046 µM. Electrodes were used to determine the DA of real samples and produced acceptable outputs.
The proposed electrochemical sensor is an exceptional advance in DA detection and may pave the way for molecular diagnostics of neurological diseases.