Brain Wealthy
    What's Hot

    Cullman Regional welcomes Kenneth Murray, MD, neurologist and sleep medicine expert.

    February 2, 2023

    Bill Focuses on Mental Health, Wellness Resources for Colorado Students

    February 2, 2023

    Leonard Nimoy Once Explained Huge Competitiveness And Anxiety On The Set Of Star Trek

    February 2, 2023
    Facebook Twitter Instagram
    Facebook Twitter Instagram
    Brain Wealthy
    • Home
    • Anxiety

      Leonard Nimoy Once Explained Huge Competitiveness And Anxiety On The Set Of Star Trek

      February 2, 2023

      Therapist Hong Kong News – Counseling and therapy practice treats post-corona depression anxiety and stress Hong Kong

      February 1, 2023

      Pokemon Scarlet & Violet players fail ‘anxiety-inducing’ shiny encounters due to jump glitch

      February 1, 2023

      Can Mindfulness Soothe Anxiety? The trial suggests yes. – Harvard Gazette

      February 1, 2023

      Best CBD for dog anxiety

      February 1, 2023
    • Emotion

      Humvee details wave of emotions since Ace to Sparks trade

      February 2, 2023

      Stephen ‘tWitch’ Boss’ mother shares emotional reaction to seeing his Gap campaign: ‘I almost called you’

      February 1, 2023

      ‘It’s like, really emotional’: Quakertown students Q&A with Super Bowl-bound Eagles player | Southeast Pennsylvania

      February 1, 2023

      Delight in Cafes: Tweets Reveal Where People Express Different Emotions in a City

      February 1, 2023

      Want to be happier?Millions of Tweets Show Your Location May Affect Your Emotions

      February 1, 2023
    • Neurology

      Cullman Regional welcomes Kenneth Murray, MD, neurologist and sleep medicine expert.

      February 2, 2023

      Repairing cerebrospinal fluid leaks may improve symptoms

      February 1, 2023

      Fear of Public Places Associated with Poor Quality of Life in Adults with Epilepsy

      February 1, 2023

      Novartis discontinues Huntington’s disease program after Phase 2b trial

      February 1, 2023

      Postmenopausal stroke risk dates back to women’s reproductive age

      February 1, 2023
    • Sleep

      What Happens During Your Sleep Cycle?

      February 2, 2023

      Centrepoint will try to sleep out this February.

      February 1, 2023

      Experience America’s Favorite Mattress Tempur-Pedic With The Best Mattress Sleep Specialists – St. George News

      February 1, 2023

      Simple remedies for a good night’s sleep

      February 1, 2023

      Joe Pera launches ‘Drift Off’ podcast to help us fall asleep (again)

      February 1, 2023
    • Brain Research

      The Brain Observatory: New Museum to Participate in Museum Month

      February 1, 2023

      who wants to live forever

      February 1, 2023

      UK company makes surprise forays

      February 1, 2023

      Actionable Strategy Report on Brain-Inspired Computing Market

      February 1, 2023

      Disparities associated with differences in brain structure among US children

      February 1, 2023
    • Brain Wealth
      1. Mental Health
      2. View All

      Bill Focuses on Mental Health, Wellness Resources for Colorado Students

      February 2, 2023

      Klamath County mental health treatment beds to double in planned expansion

      February 1, 2023

      WIU Introduces Mental Health Awareness Organization to Campus

      February 1, 2023

      Windsor Spitfires Partners with CMHA Windsor-Essex to Host Mental Health Awareness Game

      February 1, 2023

      Bill Focuses on Mental Health, Wellness Resources for Colorado Students

      February 2, 2023

      Klamath County mental health treatment beds to double in planned expansion

      February 1, 2023

      WIU Introduces Mental Health Awareness Organization to Campus

      February 1, 2023

      Windsor Spitfires Partners with CMHA Windsor-Essex to Host Mental Health Awareness Game

      February 1, 2023
    Brain Wealthy
    Home»Neurology»Autopsy shows COVID-19 in the brain
    Neurology

    Autopsy shows COVID-19 in the brain

    brainwealthy_vws1exBy brainwealthy_vws1exDecember 26, 2022No Comments5 Mins Read
    Facebook Twitter LinkedIn Telegram Pinterest Tumblr Reddit WhatsApp Email
    Share
    Facebook Twitter LinkedIn Pinterest Email


    Earlier this year, leading researchers discussed what we know and don’t know about COVID-19 and the brain. Since then, new discoveries have emerged about SARS-CoV-2 and the nervous system. This includes results from autopsy studies that showed the presence of the virus throughout the body and brain.

    How do respiratory pathogens like SARS-CoV-2 disrupt the nervous system? That was a question researchers posed in January and is still being asked almost a year later. increase.

    At the time, Avindra Nath, M.D., Ph.D., of the National Institute of Neurological Disorders and Stroke, noted that the neurological complications of COVID are varied and can be long-lasting. “They are primarily immune-mediated, with brain endothelial cells being the primary target,” he said. MedPage Today.

    Studies throughout the years have supported this view. In July, an autopsy study of nine COVID patients showed leakage of serum proteins into the brain parenchyma and vascular damage with widespread endothelial cell activation. No virus was detected in the brain.

    But in December, autopsy reports from 44 people who died of COVID-19 in the first year of the pandemic found that the SARS-CoV-2 virus had spread throughout the body, including the brain, and persisted in tissues for months. showed.

    Nevertheless, there was little evidence of inflammation or direct viral cytopathology beyond the airways, said Daniel Chertow, M.D., M.P.H., and coauthors of the NIH Clinical Center and National Institute of Allergy and Infectious Diseases. , Nature.

    “A total of 44 necropsies were performed, 11 of which allowed for detailed evaluation of the brain,” Chertow said. MedPage Today“In most individuals we have had brains [samples], found evidence of viral RNA and protein in multiple regions sampled. ”

    “And in one of those patients, using a modified Vero cell line that expresses the human ACE2 and TMPRSS2 receptors, we were able to actually culture the virus from the brain,” he continued. I was. “So we were able to show not only the presence of the viral components (RNA and protein), but also a live, replication-competent virus.”

    Several factors set this autopsy study apart, Chertow noted. The postmortem interval was short, with a median of his 22 hours, he said.

    “Additionally, at autopsy, the brain tissue was freshly dissected,” he added. “We collected tissue from 10 different regions of the brain and from each of those regions, we preserved the tissue in different ways appropriate for the kind of downstream analysis we were doing.”

    Chertow warned that the findings may not be generalizable. “Not everyone in our cohort had received the vaccine because the study was done in the first year of the pandemic, before a vaccine was available,” he said. They were elderly and had significant comorbidities.” The cohort included predominantly severe and ultimately fatal COVID cases, with outcomes in young, healthy, or vaccinated individuals. may not apply to

    Despite its limitations, this study showed that SARS-CoV-2 can spread to cells and tissues throughout the body and brain, but important questions remain open.

    “This is a meticulously conducted and detailed study that shows that SARS-CoV-2 infection is indeed systemic and involves many organ systems, including the brain,” said St. Louis. Ziyad Al-Aly, M.D., of the University of Washington observed. I am involved in research.

    “What the study does not show is a clear mechanistic explanation for the presence of inflammation, cellular pathology, or neurological complications of SARS-CoV-2 infection,” said Al-Aly. MedPage Today.

    “More needs to be done to understand the mechanisms underlying the nerve damage seen so vividly in COVID-19 patients during both the acute and long-term stages of the disease,” he added. rice field.

    Also contributing to our knowledge of COVID and the brain in 2022 was a case report of a 27-year-old epilepsy surgery patient recovering from COVID without respiratory distress.

    Extracellular vesicles isolated from her brain biopsy tissue showed the presence of viral nucleocapsid proteins associated with endothelial cell activation, fibrinogen leakage, and immune cell infiltration. neurology.

    “We never found a virus,” Nath said. MedPage Today“We found viral proteins, but not RNA.”

    Few researchers have discovered the virus, Nath noted. And even if they do find it, “they’re not finding overwhelming amounts of the virus in the brain,” he noted. “They find it in very small amounts.”

    “The question is how important it is,” he added. “Is that what drives the condition, or is it just sitting there? It’s not yet understood.”

    • Judy George covers MedPage Today’s neurology and neuroscience news, brain aging, Alzheimer’s disease, dementia, multiple sclerosis, rare diseases, epilepsy, autism, headaches, stroke, Parkinson’s disease, ALS, I write about concussions, CTE, sleep, pain and more. follow

    Disclosure

    autopsy studies in Nature was funded and supported by the NIH Clinical Center, the National Cancer Institute, the National Dental and Craniofacial Institute, and the National Institute of Allergy and Infectious Diseases. Chetow and co-authors report no competing interests.

    case report in neurology It was supported by the National Institute of Neurological Disorders and Stroke. Nath and co-authors had no relevant disclosures.

    Primary information

    Nature

    Source reference: Stein SR, et al “SARS-CoV-2 infection and persistence in humans and brains at autopsy” Nature 2022; DOI: 10.1038/s41586-022-05542-y.

    secondary source

    neurology

    Source: DeMarino C, et al “Detection of SARS-CoV-2 nucleocapsid and microvascular disease in the Brain: A case report” Neurology 2022; DOI: 10.1212/WNL.0000000000201682.





    Source link

    Share. Facebook Twitter Pinterest LinkedIn Tumblr Telegram Email
    Previous ArticleThe neuromorphic chip market is estimated to reach a value of USD 7.2 billion by 2027, registering a CAGR of 15.3%, led by top players Applied Brain Research, Inc., Brain Chip Holdings Ltd., General Vision. , HRL Laboratories.
    Next Article Increased neurological complications after COVID-19 vaccination
    brainwealthy_vws1ex
    • Website

    Related Posts

    Cullman Regional welcomes Kenneth Murray, MD, neurologist and sleep medicine expert.

    February 2, 2023

    Repairing cerebrospinal fluid leaks may improve symptoms

    February 1, 2023

    Fear of Public Places Associated with Poor Quality of Life in Adults with Epilepsy

    February 1, 2023
    Add A Comment

    Leave A Reply Cancel Reply

    Top Posts

    Subscribe to Updates

    Get the latest sports news from SportsSite about soccer, football and tennis.

    This website provides information about Brain and other things. Keep Supporting Us With the Latest News and we Will Provide the Best Of Our To Makes You Updated All Around The World News. Keep Sporting US.

    Facebook Twitter Instagram Pinterest YouTube
    Top Insights

    Top UK Stocks to Watch: Capita Shares Rise as it Unveils

    January 15, 2021
    8.5

    Digital Euro Might Suck Away 8% of Banks’ Deposits

    January 12, 2021

    Oil Gains on OPEC Outlook That U.S. Growth Will Slow

    January 11, 2021
    Get Informed

    Subscribe to Updates

    Get the latest creative news from FooBar about art, design and business.

    © 2023 brainwealthy. Designed by brainwealthy.
    • Home
    • Contact us
    • DMCA
    • Privacy Policy

    Type above and press Enter to search. Press Esc to cancel.