Carlsbad, CA January 4, 2023–(BUSINESS WIRE)–Arima Genomics, Inc., a leader in 3D genomics, today announced that by enabling a team of researchers to map the 3D genome of the human brain, it Announced that it will enter the world of analytics. per cell. This work is being conducted at multiple institutions, including the Salk Institute and the University of California, Los Angeles, under the umbrella of The BRAIN Initiative Cell Atlas Network (BICAN) and the Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative.
This work spans several multi-omics techniques, including 3D genomics, DNA methylation and RNA expression, to describe brain cells in unprecedented molecular detail, classify brain cells into precise subtypes, and identify individual brain cells. Locate the Specifically, they use his Arima Genomics kit as part of their mononuclear methyl-3C sequencing (sn-m3C-Seq) workflow. This allows simultaneous cell-by-cell investigation of genomic methylation status and 3D chromatin organization. .
“Applying 3D genomic technology at the single-cell level is an incredibly powerful approach. We are just beginning to understand its potential to uncover new biology in the brain,” said Arima Genomics. Anthony Schmitt, Ph.D., senior vice president of science at “We are very excited to partner with a multidisciplinary team to maximize the impact of this important study on the genetics of human brain function and aging.”
Using this single-cell 3D genomics approach, the team aims to better understand how the neurotypical human brain develops, functions, and ages, and hopes scientists can transform the brain into Alzheimer’s disease. It helps establish a baseline against which neurological or psychiatric conditions such as disease, autism, and depression can be compared. , and traumatic brain injury. Furthermore, by distinguishing cell types in the brain, researchers aim to elucidate the unique gene regulatory programs and cellular mechanisms that determine functional changes in aging and disease.
“Single-cell multi-omics, including 3D genomics approaches, give us a peek into the inner workings of the human genome: cell types, tissues, and organs,” said Chongyuan Luo, Ph.D., assistant professor of medicine at UCLA’s David Geffen School of Medicine. I’m here. “The single-cell data generated from this project will help create a comprehensive map of the gene regulatory landscape in human brain development, allowing scientists to understand the genetic causes of neurological and psychiatric conditions. It helps point them in the right direction when they aim to understand and how to best treat them.”
To learn more about single-cell 3D genomics, watch the webinar recording titled “Single-cell 3D genomics and the BRAIN initiative in neuroscience.”
About Arima Genomics
Arima Genomics, Inc. advances life science research through the power of 3D genomics by providing unmatched access to the sequence and structure of any genome. Arima Genomics provides cutting-edge technology for preserving the structural organization of the genome, accelerating discoveries in genomic biology and human health. For more information, please visit www.arimagenomics.com twitterLinkedIn, YouTube.
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Dr. Pamela Bentley Mills