WEDNESDAY, Jan. 4, 2023 (HealthDay News) — Antiepileptic drugs are linked to the development of Parkinson’s disease, according to a study published online Dec. 27. Department of Neurology, JAMA.
Daniel Belete (MBCh.B.), Queen Mary University of London, and colleagues used data from 1,433 individuals diagnosed with Parkinson’s disease and 8,598 matched controls to compare antiepileptic drugs with onset Parkinson’s disease. investigated the relationship with We defined exposure to antiepileptic drugs (carbamazepine, lamotrigine, levetiracetam, and sodium valproate) using regularly collected prescribing data from primary care.
The researchers observed a dose-response association between antiepileptic drug prescribing and the development of Parkinson’s disease (odds ratio 1.80), finding that more showed a tendency to increase
“To our knowledge, this is the first observational study to investigate different antiepileptic drugs and their association with the development of Parkinson’s disease. We emphasize the need for further work to support our findings, as these findings may have important implications for clinical decision-making. The underlying reason for the association needs further investigation.”
Two authors disclosed financial ties to the pharmaceutical industry.
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